Synthesis and characterization of 2-thiophen flavonoid analogue for free radical scavenging antioxidant analysis

Introduction and Aim: Currently research is focussed on the use of antioxidants in preventing oxidative stress induced diseases. Flavonoids present plant sources gaining more therapeutic importance due to their antioxidant property, but solubility some pharmacokinetic concern, diverted current study towards synthesis these flavonoids for potential. The was aimed synthesize characterize 2-thiophen flavonoid analogue free radical scavenging activity. Materials Methods: test synthetic compound PNF(3-hydroxy-2-(thiophen-2-yl)-4H-chromen-4-one) a thiophen substituted synthesized from condensation fallowed cyclization reaction laboratory DPPH, superoxide, nitric oxide, hydroxyl activity determined through established vitro methods. Results: It suggests that (PNF) possesses potent radicals with IC50 values 6.89±25?g/ml,4.04?g/ml, 2.44?g/ml 2.96?g/ml respectively. potential PNF at different concentrations(10?g-150?g) compared standard such as BHA , ascorbic acid used study. Conclusion: Results this indicates novel exhibited considerable dose dependant invitro These possible activities could be useful consider derived agent.